Osteopontin Isoforms Differentially Promote Arteriogenesis in Response to Ischemia via Macrophage Accumulation and Survival

OBJECTIVE: Osteopontin (OPN) is critical for ischemia-induced neovascularization. Unlike rodents, humans express 3 OPN isoforms (a, b, and c); however, the roles of these isoforms in post-ischemic neovascularization and cell migration remain undefined. Our objective was to determine if OPN isoforms...

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Pubblicato in:Lab Invest
Autori principali: Lee, Grace Sanghee, Salazar, Hector F., Joseph, Giji, Lok, Zoe Shin Yee, Caroti, Courtney M., Weiss, Daiana, Taylor, W. Robert, Lyle, Alicia N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311150/
https://ncbi.nlm.nih.gov/pubmed/29959420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-018-0094-8
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