Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

BACKGROUND: Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention. In this study, we simulated hepatotoxicity by treating hepatocytes derived from RA patient–derived induced...

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Publicado en:Stem Cell Res Ther
Autores principales: Kim, Juryun, Kim, Yena, Choi, Jinhyeok, Jung, Hyerin, Lee, Kijun, Kang, Jaewoo, Park, Narae, Rim, Yeri Alice, Nam, Yoojun, Ju, Ji Hyeon
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310944/
https://ncbi.nlm.nih.gov/pubmed/30594247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-1100-1
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