MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat

HIV-1 protease (PR) cleavage of the Gag polyprotein triggers the assembly of mature, infectious particles. Final cleavage of Gag occurs at the junction helix between the capsid protein CA and the SP1 spacer peptide. Here we used MicroED to delineate the binding interactions of the maturation inhibit...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Purdy, Michael D., Shi, Dan, Chrustowicz, Jakub, Hattne, Johan, Gonen, Tamir, Yeager, Mark
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310804/
https://ncbi.nlm.nih.gov/pubmed/30530702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806806115
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