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Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off
The directed evolution of enzymes for improved activity or substrate specificity commonly leads to a trade-off in stability. We have identified an activity–stability trade-off and a loss in unfolding cooperativity for a variant (3M) of Escherichia coli transketolase (TK) engineered to accept aromati...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310800/ https://ncbi.nlm.nih.gov/pubmed/30530661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812204115 |
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