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Interactome and proteome dynamics uncover immune modulatory associations of the pathogen sensing factor cGAS
Viral DNA sensing is an essential component of mammalian innate immune response. Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of cyclic dinucleotides to induce type I interferons. However, little is known about how cGAS is homeostatically maintained or regulate...
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| Publicado no: | Cell Syst |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310102/ https://ncbi.nlm.nih.gov/pubmed/30471916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.10.010 |
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