Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats

TRV027 is a biased agonist for the Angiotensin (Ang)-IItype 1 receptor (AT(1)R), able to recruit β-arrestin 2 independently of G-proteins activation. β-arrestin activation in the central nervous system (CNS) was suggested to oppose the effects of Ang-II. The present study evaluates the effect of cen...

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Udgivet i:Clin Sci (Lond)
Main Authors: Carvalho-Galvão, Alynne, Ogunlade, Blessing, Xu, Jiaxi, Silva-Alves, Cristiane R.A., Mendes-Júnior, Leônidas G., Guimarães, Drielle D., Cruz, Josiane C., Queiroz, Thyago M., Balarini, Camille M., Braga, Valdir A., Filipeanu, Catalin M., Lazartigues, Eric, de França-Silva, Maria do Socorro
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309978/
https://ncbi.nlm.nih.gov/pubmed/29903768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20180222
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