Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies

OBJECTIVES: Excessive exposure to acetaminophen (APAP, paracetamol) can cause liver injury through formation of a reactive metabolite that depletes hepatic glutathione and causes hepatocellular oxidative stress and damage. Generation of this metabolite is mediated by Cytochrome-P450 (CYP) isoforms,...

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Bibliografiske detaljer
Udgivet i:J Pharm Pharmacol
Main Authors: Cao, Lei, Kwara, Awewura, Greenblatt, David J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309961/
https://ncbi.nlm.nih.gov/pubmed/28872689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.12812
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