Addition of Anti-CD40 Monoclonal Antibody to Nonmyeloablative Conditioning with Belatacept Abrogated Allograft Tolerance Despite Induction of Mixed Chimerism

BACKGROUND: We recently reported anti-CD40 monoclonal antibody and rapamycin (aCD40/rapa) to be a reliable, nontoxic, immunosuppressive regimen for combined islet and kidney transplantation (CIKTx) in nonhuman primates (NHPs). In the current study, we attempted to induce allograft tolerance through...

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Publicado en:Transplantation
Autores principales: Oura, Tetsu, Hotta, Kiyohiko, Rosales, Ivy, Dehnadi, Abbas, Kawai, Kent, Lee, Hang, Cosimi, A. Benedict, Kawai, Tatsuo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309923/
https://ncbi.nlm.nih.gov/pubmed/30113996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000002417
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