Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits

We investigated how pathological changes in newborn hippocampal dentate granule cells (DGCs) lead to epilepsy. Using a rabies virus–mediated retrograde tracing system and a designer receptors exclusively activated by designer drugs (DREADD) chemogenetic method, we demonstrated that newborn hippocamp...

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Vydáno v:J Clin Invest
Hlavní autoři: Zhou, Qi-Gang, Nemes, Ashley D., Lee, Daehoon, Ro, Eun Jeoung, Zhang, Jing, Nowacki, Amy S., Dymecki, Susan M., Najm, Imad M., Suh, Hoonkyo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307945/
https://ncbi.nlm.nih.gov/pubmed/30507615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95731
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