Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing approach to generate a loss-of-function mutant in zebrafish col22...

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Veröffentlicht in:Dis Model Mech
Hauptverfasser: Ton, Quynh V., Leino, Daniel, Mowery, Sarah A., Bredemeier, Nina O., Lafontant, Pascal J., Lubert, Allison, Gurung, Suman, Farlow, Janice L., Foroud, Tatiana M., Broderick, Joseph, Sumanas, Saulius
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307901/
https://ncbi.nlm.nih.gov/pubmed/30541770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.033654
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