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Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis

Morphogenesis of the inner ear epithelium requires coordinated deployment of several signaling pathways, and disruptions cause abnormalities of hearing and/or balance. The FGFR2b ligands FGF3 and FGF10 are expressed throughout otic development and are required individually for normal morphogenesis,...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Urness, Lisa D., Wang, Xiaofen, Doan, Huy, Shumway, Nathan, Noyes, C. Albert, Gutierrez-Magana, Edgar, Lu, Ree, Mansour, Suzanne L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307884/
https://ncbi.nlm.nih.gov/pubmed/30504125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.170142
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