Antitumor activity of the bioreductive prodrug 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) on MDA-MB-231 cells: in vitro and in vivo

BACKGROUND: 3-(2-Nitrophenyl) propionic acid-paclitaxel (NPPA-PTX) is a paclitaxel (PTX) bioreductive prodrug synthesized by our lab. We hypothesize that NPPA-PTX can self-assemble to form nanoparticles (NPs). MATERIALS AND METHODS: In the present research, the theoretical partition coefficient (Xlo...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Duan, Xiao-Chuan, Yao, Xin, Zhang, Shuang, Xu, Mei-Qi, Hao, Yan-Li, Li, Zhan-Tao, Zheng, Xiu-Chai, Liu, Man, Li, Zhuo-Yue, Li, Hui, Wang, Jing-Ru, Feng, Zhen-Han, Zhang, Xuan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307681/
https://ncbi.nlm.nih.gov/pubmed/30636872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S186556
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