Web-based design and analysis tools for CRISPR base editing

BACKGROUND: As a result of its simplicity and high efficiency, the CRISPR-Cas system has been widely used as a genome editing tool. Recently, CRISPR base editors, which consist of deactivated Cas9 (dCas9) or Cas9 nickase (nCas9) linked with a cytidine or a guanine deaminase, have been developed. Bas...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Hwang, Gue-Ho, Park, Jeongbin, Lim, Kayeong, Kim, Sunghyun, Yu, Jihyeon, Yu, Eunchong, Kim, Sang-Tae, Eils, Roland, Kim, Jin-Soo, Bae, Sangsu
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307267/
https://ncbi.nlm.nih.gov/pubmed/30587106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2585-4
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