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Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

BACKGROUND: Hepatocellular carcinoma (HCC) remains a global challenge due to its high morbidity and mortality rates as well as poor response to treatment. The communication between tumor-derived elements and stroma plays a critical role in facilitating cancer progression of HCC. Exosomes are small e...

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Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Zhou, Yuan, Ren, Haozhen, Dai, Bo, Li, Jun, Shang, Longcheng, Huang, Jianfei, Shi, Xiaolei
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307162/
https://ncbi.nlm.nih.gov/pubmed/30591064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0965-2
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