An Acquired Epidermal Growth Factor Receptor T790M Mutation after the Addition of Bevacizumab to Preceding Erlotinib Monotherapy in a Lung Cancer Patient with Leptomeningeal Metastases

A 53-year-old man with advanced lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) exon 19 deletion received erlotinib. After 12 months of disease control with erlotinib monotherapy, leptomeningeal metastases (LM) occurred. A cerebrospinal fluid examination demonstrated a pre-exis...

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Bibliographische Detailangaben
Veröffentlicht in:Intern Med
Hauptverfasser: Tsuchiya, Kazuo, Karayama, Masato, Yasui, Hideki, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, Suda, Takafumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Japanese Society of Internal Medicine 2018
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306543/
https://ncbi.nlm.nih.gov/pubmed/30101917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2169/internalmedicine.1062-18
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