High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects

BACKGROUND: PARP-1 plays a critical role in DNA damage repair and contributes to progression of cancer. To explore the role of PARP-1 in acute myeloid leukemia (AML), we analyzed the expression of PARP-1 in AML and its relation to the clinical prognosis. Then, we investigated the efficacy and mechan...

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Udgivet i:EBioMedicine
Main Authors: Li, Xia, Li, Chenying, Jin, Jingrui, Wang, Jinghan, Huang, Jiansong, Ma, Zhixin, Huang, Xin, He, Xiao, Zhou, Yile, Xu, Yu, Yu, Mengxia, Huang, Shujuan, Yan, Xiao, Li, Fenglin, Pan, Jiajia, Wang, Yungui, Yu, Yongping, Jin, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306376/
https://ncbi.nlm.nih.gov/pubmed/30472087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.025
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