Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy

Antibody-cytokine fusion proteins (immunocytokine) exert a potent anti-cancer effect; indeed, they target the immunosuppressive tumor microenvironment (TME) due to a specific anti-tumor antibody linked to immune activating cytokines. Once bound to the target tumor, the interleukin-2 (IL-2) immunocyt...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Mortara, Lorenzo, Balza, Enrica, Bruno, Antonino, Poggi, Alessandro, Orecchia, Paola, Carnemolla, Barbara
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305397/
https://ncbi.nlm.nih.gov/pubmed/30619269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02905
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