Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis

Cigarette smoke (CS) is the main cause of chronic obstructive pulmonary disease. Surfactant protein D (SP-D) is an important anti-inflammatory protein that regulates host immune defense in the lungs. Here, we investigated the role of SP-D in a murine model of CS-induced inflammation. Pulmonary SP-D...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Pilecki, Bartosz, Wulf-Johansson, Helle, Støttrup, Christian, Jørgensen, Patricia Troest, Djiadeu, Pascal, Nexøe, Anders Bathum, Schlosser, Anders, Hansen, Søren Werner Karlskov, Madsen, Jens, Clark, Howard William, Nielsen, Claus Henrik, Vestbo, Jørgen, Palaniyar, Nades, Holmskov, Uffe, Sorensen, Grith Lykke
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305334/
https://ncbi.nlm.nih.gov/pubmed/30619359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03013
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