Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1α Promotes Viral Proliferation

In this study, we show that porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1α (nsp1α) facilitates PRRSV escape from innate immune by modulating nuclear to cytoplasmic translocation and distribution ratio of TRAIP to promote virus proliferation. Mechanistically, TR...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Shi, Peidian, Su, Yanxin, Li, Ruiqiao, Zhang, Lei, Chen, Chen, Zhang, Lilin, Faaberg, Kay, Huang, Jinhai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305329/
https://ncbi.nlm.nih.gov/pubmed/30619364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03023
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