Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties

We isolated a strain of human mycoplasma that promotes lymphomagenesis in SCID mice, pointing to a p53-dependent mechanism similar to lymphomagenesis in uninfected p53(−/−) SCID mice. Additionally, mycoplasma infection in vitro reduces p53 activity. Immunoprecipitation of p53 in mycoplasma-infected...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zella, Davide, Curreli, Sabrina, Benedetti, Francesca, Krishnan, Selvi, Cocchi, Fiorenza, Latinovic, Olga S., Denaro, Frank, Romerio, Fabio, Djavani, Mahmoud, Charurat, Man E., Bryant, Joseph L., Tettelin, Hervé, Gallo, Robert C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304983/
https://ncbi.nlm.nih.gov/pubmed/30509983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815660115
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