Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice

Neurotrophic factor NRG1 and its receptor ErbB4 play a role in GABAergic circuit assembly during development. ErbB4 null mice possess fewer interneurons, have decreased GABA release, and show impaired behavior in various paradigms. In addition, NRG1 and ErbB4 have also been implicated in regulating...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Wang, Hongsheng, Liu, Fang, Chen, Wenbing, Sun, Xiangdong, Cui, Wanpeng, Dong, Zhaoqi, Zhao, Kai, Zhang, Hongsheng, Li, Haiwen, Xing, Guanglin, Fei, Erkang, Pan, Bing-Xing, Li, Bao-Ming, Xiong, Wen-Cheng, Mei, Lin
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304932/
https://ncbi.nlm.nih.gov/pubmed/30498032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811287115
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