Palmitate Stimulates the Epithelial Sodium Channel by Elevating Intracellular Calcium, Reactive Oxygen Species, and Phosphoinositide 3-Kinase Activity

Previous studies indicate that the epithelial sodium channel (ENaC) in the kidney is upregulated in diabetes mellitus. Here, we show that ENaC single-channel activity in distal nephron cells was significantly increased by palmitate, a free fatty acid which is elevated in diabetes mellitus. We also s...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Wang, Qiu-Shi, Liang, Chen, Niu, Na, Yang, Xu, Chen, Xiao, Song, Bin-Lin, Yu, Chang-Jiang, Wu, Ming-Ming, Zhang, Zhi-Ren, Ma, He-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304918/
https://ncbi.nlm.nih.gov/pubmed/30622672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7560610
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