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Transforming of the Tumor Microenvironment: Implications for TGF-β Inhibition in the Context of Immune-Checkpoint Therapy

Significant breakthroughs have been achieved in the fields of oncogenic signaling inhibition and particularly immune-checkpoint blockade has triggered substantial enthusiasm during the last decade. Antibody-mediated blockade of negative immune-checkpoint molecules (e.g., PD-1/PD-L1, CTLA-4) has been...

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Dettagli Bibliografici
Pubblicato in:J Oncol
Autore principale: Löffek, Stefanie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304495/
https://ncbi.nlm.nih.gov/pubmed/30631358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9732939
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