Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways

BACKGROUND/PURPOSE: Pristimerin (Pris) is triterpenoid compound with many biological effects. Until now, nothing is known about its effect on doxorubicin (DOX)-induced cardiotoxicity. Hence, this study investigated the impact of Pris on DOX-induced cardiotoxic effects. MATERIALS AND METHODS: Rats we...

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Bibliografiske detaljer
Udgivet i:Cancer Manag Res
Main Authors: El-Agamy, Dina S, El-Harbi, Khaled M, Khoshhal, Saad, Ahmed, Nishat, Elkablawy, Mohamed A, Shaaban, Ahmed A, Abo-Haded, Hany M
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304079/
https://ncbi.nlm.nih.gov/pubmed/30588110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S186696
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