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Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized (13)C-methylglyoxal

Methylglyoxal is a faulty metabolite. It is a ubiquitous by-product of glucose and amino acid metabolism that spontaneously reacts with proximal amino groups in proteins and nucleic acids, leading to impairment of their function. The glyoxalase pathway evolved early in phylogeny to bring about rapid...

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Publicat a:Commun Biol
Autors principals: Shishmarev, Dmitry, Kuchel, Philip W., Pagès, Guilhem, Wright, Alan J., Hesketh, Richard L., Kreis, Felix, Brindle, Kevin M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303249/
https://ncbi.nlm.nih.gov/pubmed/30588511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0241-1
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