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Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized (13)C-methylglyoxal

Methylglyoxal is a faulty metabolite. It is a ubiquitous by-product of glucose and amino acid metabolism that spontaneously reacts with proximal amino groups in proteins and nucleic acids, leading to impairment of their function. The glyoxalase pathway evolved early in phylogeny to bring about rapid...

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Detalles Bibliográficos
Publicado en:Commun Biol
Main Authors: Shishmarev, Dmitry, Kuchel, Philip W., Pagès, Guilhem, Wright, Alan J., Hesketh, Richard L., Kreis, Felix, Brindle, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303249/
https://ncbi.nlm.nih.gov/pubmed/30588511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0241-1
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