Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability

AIMS: Paracetamol is the analgesic most used by older people. The physiological changes occurring with ageing influence the pharmacokinetics (PK) of paracetamol and its variability. We performed a population PK‐analysis to describe the PK of intravenous (IV) paracetamol in fit older people. Simulati...

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Detaylı Bibliyografya
Yayımlandı:Br J Clin Pharmacol
Asıl Yazarlar: Mian, P., van Esdonk, M. J., Olkkola, K. T., de Winter, B. C. M., Liukas, A., Spriet, I., Tibboel, D., Petrovic, M., Koch, B. C. P., Allegaert, K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303215/
https://ncbi.nlm.nih.gov/pubmed/30321459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13770
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