Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

BACKGROUND: Previously, we have demonstrated that Interleukin 13 receptor alpha 2 (IL-13Rα2) is overexpressed in approximate 78% Glioblastoma multiforme (GBM) samples. We have also demonstrated that IL-13Rα2 can serve as a target for cancer immunotherapy in several pre-clinical and clinical studies....

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Bibliographic Details
Published in:J Transl Med
Main Authors: Bhardwaj, Rukmini, Suzuki, Akiko, Leland, Pamela, Joshi, Bharat H., Puri, Raj K.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302477/
https://ncbi.nlm.nih.gov/pubmed/30572904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1746-6
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