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Bisretinoids mediate light sensitivity resulting in photoreceptor cell degeneration in mice lacking the receptor tyrosine kinase Mer

The receptor tyrosine kinase Mer is expressed by retinal pigment epithelial (RPE) cells and participates in photoreceptor outer-segment phagocytosis, a process enabling membrane renewal. Mutations in the gene encoding MERTK cause blinding retinitis pigmentosa in humans. Targeted Mertk disruption in...

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Foilsithe in:J Biol Chem
Main Authors: Zhao, Jin, Ueda, Keiko, Riera, Marina, Kim, Hye Jin, Sparrow, Janet R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302181/
https://ncbi.nlm.nih.gov/pubmed/30352873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005949
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