Inhibition of thioredoxin-dependent H(2)O(2) removal sensitizes malignant B-cells to pharmacological ascorbate

L-ascorbate (L-ASC) is a widely-known dietary nutrient which holds promising potential in cancer therapy when given parenterally at high doses. The anticancer effects of L-ASC involve its autoxidation and generation of H(2)O(2), which is selectively toxic to malignant cells. Here we present that thi...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Graczyk-Jarzynka, Agnieszka, Goral, Agnieszka, Muchowicz, Angelika, Zagozdzon, Radoslaw, Winiarska, Magdalena, Bajor, Malgorzata, Trzeciecka, Anna, Fidyt, Klaudyna, Krupka, Joanna Alicja, Cyran, Julia, Szczygiel, Kacper, Efremov, Dimitar G., Gobessi, Stefania, Jagielski, Adam, Siudakowska, Karolina, Bobrowicz, Malgorzata, Klopotowska, Marta, Barankiewicz, Joanna, Malenda, Agata, Lech-Maranda, Ewa, Miazek-Zapala, Nina, Skarzynski, Piotr Henryk, Domagala, Antoni, Golab, Jakub, Firczuk, Malgorzata
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302138/
https://ncbi.nlm.nih.gov/pubmed/30576925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.11.020
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