The role of JNK phosphorylation as a molecular target to enhance adenovirus replication, oncolysis and cancer therapeutic efficacy

Oncolytic adenoviruses (Ads) are cancer selective tumoricidal agents; however their mechanism of Ad-mediated cancer cell lysis, or oncolysis, remains undefined. This report focuses upon the autophagy mediator c-JUN n-terminal kinase (JNK) and its effects upon Ad oncolysis and replication. Previously...

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Publicat a:Cancer Biol Ther
Autors principals: Wechman, Stephen L., Rao, Xiao-Mei, Gomez-Gutierrez, Jorge G., Zhou, Heshan Sam, McMasters, Kelly M.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301809/
https://ncbi.nlm.nih.gov/pubmed/30067431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1491503
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