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Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development

Kynurenines, the products of tryptophan oxidative degradation, are involved in multiple neuropathologies, such as Huntington's chorea, Parkinson's disease, senile dementia, etc. The major cause for hydroxykynurenines's neurotoxicity is the oxidative stress induced by the reactive oxyg...

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Podrobná bibliografie
Vydáno v:PLoS Comput Biol
Hlavní autoři: Zhuravlev, Aleksandr V., Vetrovoy, Oleg V., Savvateeva-Popova, Elena V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301705/
https://ncbi.nlm.nih.gov/pubmed/30532237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006672
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