The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection

The opportunistic pathogen Burkholderia cenocepacia is particularly life-threatening for cystic fibrosis (CF) patients. Chronic lung infections with these bacteria can rapidly develop into fatal pulmonary necrosis and septicaemia. We have recently shown that macrophages are a critical site for repli...

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Vydáno v:PLoS Pathog
Hlavní autoři: Gomes, Margarida C., Tasrini, Yara, Subramoni, Sujatha, Agnoli, Kirsty, Feliciano, Joana R., Eberl, Leo, Sokol, Pamela, O’Callaghan, David, Vergunst, Annette C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301696/
https://ncbi.nlm.nih.gov/pubmed/30513124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007473
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