Immature lung TNFR2(−) conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo

Cyclic dinucleotides (CDNs), including cyclic di-GMP (CDG), are promising vaccine adjuvants in pre-clinical/clinical trials. The in vivo mechanisms of CDNs is not clear. Here we investigated the roles of lung DCs subsets in promoting CDG mucosal adjuvant responses in vivo. Using genetically modified...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Mansouri, Samira, Patel, Seema, Katikaneni, Divya S, Blaauboer, Steven M, Wang, Wei, Schattgen, Stefan, Fitzgerald, Katherine, Jin, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301145/
https://ncbi.nlm.nih.gov/pubmed/30327534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0098-0
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