Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration

Development of a preventive strategy against tubular damage associated with proteinuria is of great importance. Recently, free fatty acid (FFA) toxicities accompanying proteinuria were found to be a main cause of tubular damage, which was aggravated by insufficiency of peroxisome proliferator-activa...

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Publicado en:Toxicol Appl Pharmacol
Autores principales: Takahashi, Kyoko, Kamijo, Yuji, Hora, Kazuhiko, Hashimoto, Koji, Higuchi, Makoto, Nakajima, Takero, Ehara, Takashi, Shigematsu, Hidekazu, Gonzalez, Frank J., Aoyama, Toshifumi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300991/
https://ncbi.nlm.nih.gov/pubmed/21338618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.02.012
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