PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

Biomechanical stress and cytoskeletal remodeling are key determinants of cellular homeostasis and tissue responses to mechanical stimuli and injury. Here we document the increased activity of gelsolin, an actin filament severing and capping protein, in failing human hearts. Deletion of gelsolin prev...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Patel, Vaibhav B., Zhabyeyev, Pavel, Chen, Xueyi, Wang, Faqi, Paul, Manish, Fan, Dong, McLean, Brent A., Basu, Ratnadeep, Zhang, Pu, Shah, Saumya, Dawson, John F., Pyle, W. Glen, Hazra, Mousumi, Kassiri, Zamaneh, Hazra, Saugata, Vanhaesebroeck, Bart, McCulloch, Christopher A., Oudit, Gavin Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300608/
https://ncbi.nlm.nih.gov/pubmed/30568254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07812-8
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