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NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice

Neurokinin B (NKB) signaling is critical for reproduction in all studied species. The existing consensus is that NKB induces GnRH release via kisspeptin (Kiss1) stimulation in the arcuate nucleus. However, the stimulatory action of NKB is dependent on circulating estrogen (E(2)) levels, without whic...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Fergani, Chrysanthi, Leon, Silvia, Padilla, Stephanie L, Verstegen, Anne MJ, Palmiter, Richard D, Navarro, Victor M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300354/
https://ncbi.nlm.nih.gov/pubmed/30565563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40476
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