Design and Evaluation of Novel Glutaminase Inhibitors

A novel set of GAC (Kidney Glutaminase Isoform C) inhibitors able to inhibit the enzymatic activity of GAC and the growth of the triple negative MDA-MB-231 breast cancer cells with low nanomolar potency is described. Compounds in this series have a reduced number of rotatable bonds, improved ClogPs,...

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Опубликовано в: :Bioorg Med Chem
Главные авторы: McDermott, Lee A., Iyer, Prema, Vernetti, Larry, Rimer, Shawn, Sun, Jingran, Boby, Melissa, Yang, Tianyi, Fioravanti, Michael, O’Neil, Jason, Wang, Liwei, Drakes, Dylan, Katt, William, Huang, Qingqiu, Cerione, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300166/
https://ncbi.nlm.nih.gov/pubmed/26988803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.03.009
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