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PARPs in genome stability and signal transduction: implications for cancer therapy

The poly(ADP-ribose) polymerase (PARP) superfamily of enzymes catalyses the ADP-ribosylation (ADPr) of target proteins by using nicotinamide adenine dinucleotide (NAD(+)) as a donor. ADPr reactions occur either in the form of attachment of a single ADP-ribose nucleotide unit on target proteins or in...

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Publicat a:Biochem Soc Trans
Autors principals: Palazzo, Luca, Ahel, Ivan
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299239/
https://ncbi.nlm.nih.gov/pubmed/30420415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20180418
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