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Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel
By vacuolar patch-clamp and Ca(2+) imaging experiments, we show that the yeast vacuolar transient receptor potential (TRPY) channel 1 is activated by cytosolic Ca(2+) and inhibited by Ca(2+) from the vacuolar lumen. The channel is cooperatively affected by vacuolar Ca(2+) (Hill coefficient, 1.5), su...
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| 發表在: | iScience |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6299153/ https://ncbi.nlm.nih.gov/pubmed/30572205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.11.037 |
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