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A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1
Botulinum neurotoxin (BoNT) delivers its protease domain across the vesicle membrane to enter the neuronal cytosol upon vesicle acidification. This process is mediated by its translocation domain (H(N)), but the molecular mechanism underlying membrane insertion of H(N) remains poorly understood. Her...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6299077/ https://ncbi.nlm.nih.gov/pubmed/30560862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07789-4 |
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