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Matrix Metalloproteinase-9 Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake

Here, we have exploited the heightened concentration of MMP-9 to induce surface-conversional properties of nanogels with the aim of tumor-specific enhanced cellular uptake. A modular polymeric nanogel platform was designed and synthesized for facile formulation and validation of MMP-9 mediated de-PE...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biomacromolecules
Hauptverfasser: Gordon, Mallory R., Zhao, Bo, Anson, Francesca, Fernandez, Ann, Singh, Khushboo, Homyak, Celia, Canakci, Mine, Vachet, Richard W., Thayumanavan, S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298948/
https://ncbi.nlm.nih.gov/pubmed/29360342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b01659
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