Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1

Tight binding of Gdown1 represses RNA polymerase II (Pol II) function in a manner that is reversed by Mediator, but the structural basis of these processes is unclear. Although Gdown1 is intrinsically disordered, its Pol II interacting domains were localized and shown to occlude TFIIF and TFIIB bind...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Jishage, Miki, Yu, Xiaodi, Shi, Yi, Ganesan, Sai J., Chen, Wei-Yi, Sali, Andrej, Chait, Brian T., Asturias, Francisco J., Roeder, Robert G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298426/
https://ncbi.nlm.nih.gov/pubmed/30190596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0118-5
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