Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice

A subset of midbrain dopamine (DA) neurons express vesicular glutamate transporter 2 (VgluT2), which facilitates synaptic vesicle loading of glutamate. Recent studies indicate that such expression can modulate DA-dependent reward behaviors, but little is known about functional consequences of DA neu...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Shen, Hui, Marino, Rosa Anna M., McDevitt, Ross A., Bi, Guo-Hua, Chen, Kai, Madeo, Graziella, Lee, Pin-Tse, Liang, Ying, De Biase, Lindsay M., Su, Tsung-Ping, Xi, Zheng-Xiong, Bonci, Antonello
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298109/
https://ncbi.nlm.nih.gov/pubmed/30442663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800886115
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