Mineralocorticoid receptor antagonism improves parenchymal arteriole dilation via a TRPV4-dependent mechanism and prevents cognitive dysfunction in hypertension

Hypertension and mineralocorticoid receptor activation cause cerebral parenchymal arteriole remodeling; this can limit cerebral perfusion and contribute to cognitive dysfunction. We used a mouse model of angiotensin II-induced hypertension to test the hypothesis that mineralocorticoid receptor activ...

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Bibliografski detalji
Izdano u:Am J Physiol Heart Circ Physiol
Glavni autori: Diaz-Otero, Janice M., Yen, Ting-Chieh, Fisher, Courtney, Bota, Daniel, Jackson, William F., Dorrance, Anne M.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297805/
https://ncbi.nlm.nih.gov/pubmed/30118343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00207.2018
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