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Doxorubicin-loaded dual-functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo

A novel GHH copolymer was synthesized using hyaluronic acid modified with glycyrrhetinic acid and L-histidine (His), and doxorubicin-loaded GHH nanoparticles (DOX/GHH) were prepared for liver-targeted drug delivery and pH-responsive drug release. In the present study, GHH nanoparticles were characte...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Tian, Guixiang, Sun, Xiue, Bai, Jingkun, Dong, Jinhua, Zhang, Bo, Gao, Zhiqin, Wu, Jingliang
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297777/
https://ncbi.nlm.nih.gov/pubmed/30483793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.9687
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