Influence of the IGFBP3-202A/C Gene Polymorphism on Clinical Features and Surgery Outcome in Acromegalic Patients

Purpose: Excess growth hormone (GH) secretion in acromegaly patients results in increased levels of IGF-1 expression, which causes the clinical manifestations of acromegaly. IGF-1 levels are attenuated by IGFBP3, and a polymorphism in the promoter of IGFBP3 is known to affect the circulating level o...

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Dettagli Bibliografici
Pubblicato in:Front Endocrinol (Lausanne)
Autori principali: Gao, Ming, Zhu, Bin, Li, Ping, Zhang, Guojun, Chen, Kelin, Lv, Hong, Ma, Ruimin, Zhang, Limin, Fan, Yubo, Kang, Xixiong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297192/
https://ncbi.nlm.nih.gov/pubmed/30619084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2018.00751
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