Optimization of Electrospray Ionization Source Parameters for Lipidomics To Reduce Misannotation of In-Source Fragments as Precursor Ions

Lipidomics requires the accurate annotation of lipids in complex samples to enable determination of their biological relevance. We demonstrate that unintentional in-source fragmentation (ISF, common in lipidomics) generates ions that have identical masses to other lipids. Lysophosphatidylcholines (L...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Gathungu, Rose M., Larrea, Pablo, Sniatynski, Matthew J., Marur, Vasant R., Bowden, John A., Koelmel, Jeremy P., Starke-Reed, Pamela, Hubbard, Van S., Kristal, Bruce S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297073/
https://ncbi.nlm.nih.gov/pubmed/30265528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b03436
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