Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) Parathyroid Tumors Demonstrate Distinctive Morphologic Features

The gene CDC73 (previously known as HRPT2) encodes the protein parafibromin. Biallelic mutation of CDC73 is strongly associated with malignancy in parathyroid tumors. Heterozygous germline mutations cause hyperparathyroidism jaw tumor syndrome,which is associated with a high life-time risk of parath...

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Veröffentlicht in:Am J Surg Pathol
Hauptverfasser: Gill, Anthony J., Lim, Grace, Cheung, Veronica K.Y., Andrici, Juliana, Perry-Keene, Joanna L., Paik, Julie, Sioson, Loretta, Clarkson, Adele, Sheen, Amy, Luxford, Catherine, Elston, Marianne S., Meyer-Rochow, Goswin Y., Nano, M. Teresa, Kruijff, Schelto, Engelsman, Anton F., Sywak, Mark, Sidhu, Stanley B., Delbridge, Leigh W., Robinson, Bruce G., Marsh, Deborah J., Toon, Christopher W., Chou, Angela, Clifton-Bligh, Roderick J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer Health, Inc 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296846/
https://ncbi.nlm.nih.gov/pubmed/29324469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000001017
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