The ruxolitinib effect: understanding how molecular pathogenesis and epigenetic dysregulation impact therapeutic efficacy in myeloproliferative neoplasms

The myeloproliferative neoplasms (MPN), polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are linked by a propensity to thrombosis formation and a risk of leukaemic transformation. Activation of cytokine independent signalling through the JAK/STAT cascade is a f...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Greenfield, Graeme, McPherson, Suzanne, Mills, Ken, McMullin, Mary Frances
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296062/
https://ncbi.nlm.nih.gov/pubmed/30558676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1729-7
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