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Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity

An increase in oxidative protein damage is a leading contributor to the age-associated decline in oocyte quality. By removing such damaged proteins, the proteasome plays an essential role in maintaining the fidelity of oocyte meiosis. In this study, we established that decreased proteasome activity...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Mihalas, Bettina P., Bromfield, Elizabeth G., Sutherland, Jessie M., De Iuliis, Geoffry N., McLaughlin, Eileen A., Aitken, R. John, Nixon, Brett
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2018
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295717/
https://ncbi.nlm.nih.gov/pubmed/30305393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005751
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