Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity

An increase in oxidative protein damage is a leading contributor to the age-associated decline in oocyte quality. By removing such damaged proteins, the proteasome plays an essential role in maintaining the fidelity of oocyte meiosis. In this study, we established that decreased proteasome activity...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Mihalas, Bettina P., Bromfield, Elizabeth G., Sutherland, Jessie M., De Iuliis, Geoffry N., McLaughlin, Eileen A., Aitken, R. John, Nixon, Brett
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295717/
https://ncbi.nlm.nih.gov/pubmed/30305393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005751
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