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Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity
An increase in oxidative protein damage is a leading contributor to the age-associated decline in oocyte quality. By removing such damaged proteins, the proteasome plays an essential role in maintaining the fidelity of oocyte meiosis. In this study, we established that decreased proteasome activity...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6295717/ https://ncbi.nlm.nih.gov/pubmed/30305393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005751 |
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