Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity

An increase in oxidative protein damage is a leading contributor to the age-associated decline in oocyte quality. By removing such damaged proteins, the proteasome plays an essential role in maintaining the fidelity of oocyte meiosis. In this study, we established that decreased proteasome activity...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Mihalas, Bettina P., Bromfield, Elizabeth G., Sutherland, Jessie M., De Iuliis, Geoffry N., McLaughlin, Eileen A., Aitken, R. John, Nixon, Brett
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2018
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295717/
https://ncbi.nlm.nih.gov/pubmed/30305393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005751
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