Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity

An increase in oxidative protein damage is a leading contributor to the age-associated decline in oocyte quality. By removing such damaged proteins, the proteasome plays an essential role in maintaining the fidelity of oocyte meiosis. In this study, we established that decreased proteasome activity...

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發表在:J Biol Chem
Main Authors: Mihalas, Bettina P., Bromfield, Elizabeth G., Sutherland, Jessie M., De Iuliis, Geoffry N., McLaughlin, Eileen A., Aitken, R. John, Nixon, Brett
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2018
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295717/
https://ncbi.nlm.nih.gov/pubmed/30305393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005751
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